- Original Article
- Treatment of Aplastic Anemia
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Nak Gyun Chung, Kyu Jin Bhang, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
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Clin Exp Pediatr. 1993;36(8):1059-1066. Published online August 15, 1993
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We performed this study to evaluate the therapeutic responses of bone marrow transplantation and immunosuppressive therapy for aplastic anemia in 103 cases(68 severe and 35 moderate). Among them, 15 cases with severe aplastic anemia having HLA-identical sibling donor underwent bone marrow transplantation, and cases (53 severe and 35 moderate cases) without available HLA-identical sibling donor had received immunosuppressive therapy using... |
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- Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
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Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
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Clin Exp Pediatr. 1993;36(8):1067-1072. Published online August 15, 1993
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Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence... |
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- Case Report
- A Case of Bile Peritonitis Due to Spontaneous Perforation of Choledochal Cyst in Infant
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Yong Gi Kim, Byung Chan Lee, Woo Gun Choi, Byung Churl Lee, Kyong Su Lee
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Clin Exp Pediatr. 1993;36(7):1039-1043. Published online July 15, 1993
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Bile peritonitis due to spontaneous perforation of choledochal cyst is a rare disease and the etiology of spontaneous perforation is unknown in most of infant cases.
Recently, we experienced a case of bile peritonitis caused by spontaneous perforation of choledochal cyst in a 6 month-old female infant. She had progressive abdominal distention with ascites, mild jaundice and intermittent passage of acholic... |
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- Original Article
- Treatment of severe aplastic anemia: comparison between bone marrow transplantation and immunomodulation.
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Dae Chul Jeong, Sung Dong Choi, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Du Bong Lee
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Clin Exp Pediatr. 1991;34(2):172-179. Published online February 28, 1991
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Twenty, six children younger than 15 years with severe aplastic anemia underwent either bone
marrow transplantation or immunomodulation therapy (antilymphocyte globulin with cyclosporin A
therapy).
Six patients who had an HLA-identical sibling donor underwent bone marrow transplantation after
conditioning with cyclophosphamide, procarbazine and antilymphocyte globulin. Twenty children
who did not have an HLA-identical donor recieved antilymphocyte globulin and cyclosporin A.
The results were as follows;
1) Hematologic responses:... |
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- Two cases of hybrid leukemia.
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Sung Dong Choi, Dae Chul Jung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee
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Clin Exp Pediatr. 1991;34(1):130-136. Published online January 31, 1991
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The hybrid acute leukemia is defined as acute leukemia with both myeloid and lymphoid features.
We experienced and report two cases of hybrid leukemia which were identified by morpholgy,
cytochemical stain, reactivity with monoclonal antibody, analysis of immunoglobulin and T cell
receptor genes rearrangement in 14 years old boy and 10 years old girl. |
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- Immunomodulation Therapy in Children with Aplastic Anemia.
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Won Suk Suh, Ki Sik Min, Woo Gun Choi, Hack Ki Kim, Kyoung Sn Lee, Soon Yong Lee
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Clin Exp Pediatr. 1990;33(2):170-177. Published online February 28, 1990
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Thirty patients with aplastic anemia(fifteen severe aplastic anemia and fifteen moderate aplastic
anemia) treated with antilymphocyte globulin and cyclosporin A as a kind of immunomodulation
therapy were studied by analysing hematologic reseponses and complications.
The results were as follows;
1) Nineteen out of thirty patients (63.3%) treated with anti lymphocyte globulin plus cyclosporin A
showed responses (complete response of 33.3%, partial response of 30.0%).
2) Hematologic responses according... |
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